Chen Chen Selected Research

Therapeutic Uses

4/2024	Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
4/2024	Allergenicity Modulation of Casein with the Modifications of Linearization, Cross-Linking, and Glycation via the Regulation of Th1/Th2 Homeostasis.
4/2024	Functional modification of recombinant brain-derived neurotrophic factor and its protective effect against neurotoxicity.
3/2024	GSH-activable heterotrimeric nano-prodrug for precise synergistic therapy of TNBC.
10/2023	Structural-Activity Relationship-Inspired the Discovery of Saturated Fatty Acids as Novel Colistin Enhancers.
10/2023	Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogenesis by upregulating autophagy via the AMPK/mTOR pathway.
3/2023	Antimicrobial peptides as promising antibiotic adjuvants to combat drug-resistant pathogens.
3/2023	The high dose of inulin exacerbated food allergy through the excess accumulation of short-chain fatty acids in a BABL/c mouse model.
12/2022	Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19：a meta-analysis.
11/2022	Effects of Luteolin on Biofilm of Trueperella pyogenes and Its Therapeutic Effect on Rat Endometritis.

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Chen Chen Research Topics

Disease

560	Neoplasms (Cancer) 05/2024 - 05/2002
162	Inflammation (Inflammations) 05/2024 - 03/2007
117	Infections 05/2024 - 04/2009
100	Neoplasm Metastasis (Metastasis) 04/2024 - 07/2007
67	Breast Neoplasms (Breast Cancer) 12/2023 - 01/2010
51	Stroke (Strokes) 03/2024 - 08/2011
51	Hypertension (High Blood Pressure) 11/2023 - 08/2011
49	Fibrosis (Cirrhosis) 04/2024 - 12/2004
47	Cognitive Dysfunction 03/2024 - 01/2014
46	Insulin Resistance 04/2024 - 01/2006
45	Alzheimer Disease (Alzheimer's Disease) 05/2024 - 11/2006
45	Colorectal Neoplasms (Colorectal Cancer) 04/2024 - 05/2011
44	Heart Failure 05/2024 - 03/2004
44	Lung Neoplasms (Lung Cancer) 04/2024 - 07/2009
41	Carcinoma (Carcinomatosis) 04/2024 - 05/2002
40	COVID-19 03/2024 - 01/2020
40	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2024 - 12/2015
39	Obesity 04/2024 - 06/2003
38	Carcinogenesis 04/2024 - 02/2011
36	Cardiovascular Diseases (Cardiovascular Disease) 04/2024 - 01/2006
36	Hypoxia (Hypoxemia) 01/2024 - 01/2012
34	Body Weight (Weight, Body) 04/2024 - 06/2003
34	Ischemic Stroke 03/2024 - 11/2013
33	Hepatocellular Carcinoma (Hepatoma) 03/2024 - 01/2012
32	Glioma (Gliomas) 12/2023 - 02/2012
29	Type 2 Diabetes Mellitus (MODY) 05/2024 - 06/2007
29	Wounds and Injuries (Trauma) 03/2024 - 03/2007
29	Nasopharyngeal Carcinoma 04/2023 - 07/2011
28	Pain (Aches) 05/2024 - 07/2008
26	Hypertrophy 09/2023 - 09/2012
26	Ischemia 01/2023 - 03/2005
24	Neuroinflammatory Diseases 05/2024 - 10/2019
24	Hemorrhage 04/2024 - 07/2013
24	Ovarian Neoplasms (Ovarian Cancer) 03/2024 - 08/2010
24	Stomach Neoplasms (Stomach Cancer) 01/2024 - 07/2007
22	Cardiomegaly (Heart Hypertrophy) 05/2024 - 08/2013
22	Triple Negative Breast Neoplasms 05/2024 - 03/2014
21	Adenocarcinoma of Lung 02/2024 - 01/2017
20	Atherosclerosis 03/2024 - 04/2010
20	Non-alcoholic Fatty Liver Disease 02/2024 - 01/2015
20	Myocardial Infarction 09/2023 - 03/2005
20	Pancreatitis 01/2022 - 02/2009
18	Virus Diseases (Viral Diseases) 03/2024 - 01/2014
18	Sepsis (Septicemia) 01/2024 - 07/2011
17	Pancreatic Neoplasms (Pancreatic Cancer) 05/2024 - 12/2009
17	Reperfusion Injury 04/2024 - 01/2012
17	Colonic Neoplasms (Colon Cancer) 04/2024 - 09/2012
17	Atrial Fibrillation 01/2024 - 07/2012
17	Necrosis 09/2023 - 02/2012
16	Leukemia 05/2024 - 12/2007
16	Autoimmune Diseases (Autoimmune Disease) 04/2024 - 06/2014
16	Adenocarcinoma 01/2024 - 05/2013
16	Squamous Cell Carcinoma of Head and Neck 01/2023 - 01/2015
16	Brain Ischemia (Cerebral Ischemia) 12/2022 - 06/2009

Drug/Important Bio-Agent (IBA)

222	Proteins (Proteins, Gene)FDA Link 04/2024 - 05/2002
165	Biomarkers (Surrogate Marker)IBA 04/2024 - 05/2011
81	MicroRNAs (MicroRNA)IBA 05/2024 - 01/2012
67	CytokinesIBA 04/2024 - 03/2007
59	Messenger RNA (mRNA)IBA 04/2024 - 03/2005
55	Long Noncoding RNAIBA 05/2024 - 01/2015
54	Glucose (Dextrose)FDA LinkGeneric 04/2024 - 04/2011
51	LipidsIBA 02/2024 - 02/2010
48	RNA (Ribonucleic Acid)IBA 04/2024 - 01/2013
43	DNA (Deoxyribonucleic Acid)IBA 02/2024 - 05/2009
37	Therapeutic UsesIBA 04/2024 - 05/2002
36	EnzymesIBA 04/2024 - 06/2009
34	VaccinesIBA 01/2024 - 05/2009
33	Immune Checkpoint InhibitorsIBA 01/2024 - 12/2018
32	Insulin (Novolin)FDA Link 01/2024 - 01/2006
30	Interleukin-6 (Interleukin 6)IBA 04/2024 - 04/2009
30	Circular RNAIBA 04/2024 - 10/2017
29	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2024 - 05/2002
27	AntioxidantsIBA 12/2023 - 05/2010
26	Oxygen (Dioxygen)IBA 05/2024 - 12/2012
26	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2024 - 11/2011
26	Cisplatin (Platino)FDA LinkGeneric 04/2024 - 07/2014
26	Anti-Bacterial Agents (Antibiotics)IBA 01/2024 - 06/2010
26	AntigensIBA 12/2023 - 04/2005
24	Small Interfering RNA (siRNA)IBA 01/2023 - 10/2009
21	AcidsIBA 04/2024 - 02/2010
21	LigandsIBA 04/2024 - 01/2006
20	AntibodiesIBA 05/2024 - 11/2011
20	Triglycerides (Triacylglycerol)IBA 03/2024 - 02/2017
19	InflammasomesIBA 05/2024 - 07/2015
19	ChemokinesIBA 01/2024 - 01/2016
19	Hormones (Hormone)IBA 01/2024 - 05/2002
19	CholesterolIBA 12/2023 - 02/2010
19	Cytochrome P-450 CYP2J2 (CYP2J2)IBA 12/2021 - 07/2007
18	Transcription Factors (Transcription Factor)IBA 01/2024 - 01/2011
18	CollagenIBA 09/2023 - 09/2012
17	Amyloid (Amyloid Fibrils)IBA 05/2024 - 01/2017
17	salicylhydroxamic acid (SHAM)IBA 09/2023 - 03/2005
17	SeleniumIBA 03/2023 - 08/2012
17	Peptides (Polypeptides)IBA 01/2022 - 11/2004
16	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2024 - 08/2010

Therapy/Procedure

242	Therapeutics 04/2024 - 06/2003
77	Drug Therapy (Chemotherapy) 05/2024 - 01/2012
76	Immunotherapy 04/2024 - 10/2009
31	Radiotherapy 07/2023 - 01/2013
17	Chinese Traditional Medicine (Traditional Chinese Medicine) 04/2024 - 04/2011